美國(guó)密蘇里大學(xué)2024年招聘博士后（生物化學(xué)方向）

密蘇里大學(xué)（University of Missouri），簡(jiǎn)稱(chēng)“UM”，1839年創(chuàng)建于美國(guó)密蘇里州中部城市哥倫比亞，是當(dāng)時(shí)密西西比河西岸唯一的大學(xué)。該�，F(xiàn)已發(fā)展成為著名的密蘇里州大學(xué)系統(tǒng)，擁有四個(gè)校區(qū)，分別是哥倫比亞校區(qū)（Columbia）、羅拉校區(qū)（Rolla）、堪薩斯城校區(qū)（Kansas City）和圣路易斯校區(qū)（St. Louis），共有學(xué)生約63,000名。因在歷史上密蘇里大學(xué)創(chuàng)建于密蘇里州哥倫比亞市，所以密蘇里大學(xué)通常又特指密蘇里大學(xué)哥倫比亞分校。

Post-doc/staff openings: AAV structure, cell entry & gene therapy

Employer

University of Missouri - Biochemistry

Location

Columbia, Missouri (US)

Salary

Competitive, commensurate with experience.

Closing date

Mar 9, 2024

Discipline

Life Sciences, Biophysics, Computational Biology, Structural Biology, Virology

Position Type

Full Time

Job Type

Postdoc, Research Scientist, Staff Scientist

Organization Type

Academia

Post-doctoral and staff positions are open for structural studies of AAV, the gene therapy vector, and its host cell interactions, and separately, for computer methods development. Adeno-associated virus is the leading vector for human gene therapy and recently approved in treatments of SMA and hemophilia A & B. Our studies of AAV entry and trafficking advances fundamental virology and lay a key foundation in further development of gene therapies. Following our X-ray structure of AAV and identification of host factor dependencies through genome-wide screens, we have solved cryo-EM structures of complexes with the entry receptor. Focus is now on the trafficking of AAV into the nucleus. Those with training in any area of structural biophysics or molecular biology are welcome to apply. Those with experience in software engineering can be considered for separate research into cryo-EM structure refinement methods. Appointments at the University of Missouri can be as post-doctoral fellows or as research staff with a supervisory role, depending on experience. Applicants should visit https://chapman.missouri.edu/openings/ and apply to the position of interest using the link provided. A CV should be uploaded with a cover letter briefly summarizing research experience and interests, and with the contact details for three referees. Applications will be reviewed until the positions are filled. Enquiries should be directed to Michael Chapman (biochemchair@missouri.edu).

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