Postdoctoral positions are available at the Benaroya Research Institute (BRI) in Seattle, Washington. We are committed to winning the fight against autoimmune diseases such as type 1 diabetes, rheumatoid arthritis, inflammatory bowel disease and multiple sclerosis, and immune system diseases such as allergies and asthma. BRI is an internationally recognized medical research institute that accelerates discovery by tackling questions from every angle, translating immunology breakthroughs into clinical therapies and healthier patients.

As a non-profit organization within the Virginia Mason Health System, BRI oversees all clinical research at Virginia Mason and BRI, uniquely combining the expertise of a world-renowned medical research institute with the remarkable care of a healthcare quality leader.  BRI supports Virginia Mason clinical investigators in studies across a wide variety of diseases and conditions, such as cardiology and cancer, in addition to autoimmune diseases, allergy and asthma.

The Harrison Lab at the Benaroya Research Institute (BRI) in Seattle, WA is seeking highly-motivated postdoctoral candidates in the areas of mucosal immunology, specifically T and B cell responses to commensal microbes.

The Harrison Lab works to understand the mechanisms controlling host-microbe interactions at barrier sites such as the skin and gastrointestinal tract. We study how our resident commensal microbes influence the development, education and function of our immune system. To do so, we utilize a multi-disciplinary approach combining development and implementation of tools to track commensal-specific T and B cells in healthy and inflamed tissues, with single-cell and population level transcriptomics and epigenetic analyses of T and B cell differentiation to investigate how the host mounts and regulates immunity to the microbiome.

Potential projects in the Harrison Lab will build on exciting recent findings including:

• The transcriptional and epigenetic basis of commensal-specific T cell differentiation during healthy immune responses and immune-mediated diseases.

• Post-transcriptional regulation of tissue-resident T cell function.

• T cell-epithelial cell cross-talk during wound healing.

• Induction and regulation of commensal-specific B cells in the gastrointestinal tract.

A recent, or anticipated, PhD in Immunology is required. Experience in immunology, molecular biology and/or bioinformatics-based analysis of epigenetic/transcriptomic datasets are strongly preferred.

The Ray Lab is seeking highly-motivated postdoctoral candidates in the areas of genomics, immunology, technology development, and statistics/bioinformatics.

The Ray lab studies how human genetic variation and epigenetic states of immune cells alter susceptibility to autoimmune diseases. The lab performs large-scale genomic experiments using CRISPR-mediated silencing of active regions of the genome, DNA base editing, massively parallel reporter assays, and other methodologies to find regions of the genome that promote risk for disease.

Potential projects in the Ray Lab may focus on:

• The mechanisms of disease-associated genetic variants using massively parallel perturbations and base editing approaches in human cells.

• The chromatin states in human T cell subsets in the context of autoimmune diseases.

• Identifying regulatory regions important to T cell function in mice and humans.

A recent, or anticipated PhD is required, preferentially in immunology, engineering or statistics.  Experience with analysis of sequencing data, animal models, and primary immune cells is preferable but not essential.

To apply for these positions visit https://careers-benaroyaresearch.icims.com/jobs/search.

Visit BenaroyaResearch.org or follow Benaroya Research Institute on Facebook, LinkedIn or Twitter to learn more.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, disability or protected veteran status.

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